SYNERGIST EYE NIGHT HP Retinoate + Peptide Complex

Clinically proven combination of ingredients reduces


Clinical data on Lex & Jong's Skin Care’s Synergist Eye Night overviews patient feedback, measurements, and photographs.



Hydroxypinacolone Retinoate, a cosmetic grade ester of all-trans retinoic acid, is found in brandMD® Skin Care’s Synergist Eye Night. This skin care active ingredient belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of Vitamin A capable of binding to retinoid receptors. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion is switched on. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Stimulating these age-defying processes in the skin is critical for fighting and reversing signs of aging.

Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. As we age our skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Hydroxypinacolone Retinoate helps renew skin plumpness, elasticity, and hydration to provide a radiant and fresh appearance. More- over, Hydroxypinacolone Retinoate stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. The effectiveness of Hydroxypinacolone Retinoate at filling lines and wrinkles can be seen in Image 1. Hydroxypinacolone Retinoate is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion.

Scientific clinical data before and after photos of Synergist Eye Night's effectiveness on wrinkle reduction

Image 1. Dramatic reduction of lines and wrinkles was observed after 14 day Hydroxypinacolone Retinoate application



Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. Retinoic acid is a topically applied ingredient recognized for its anti-aging benefits, however, it can be irritating to skin and is sold as a prescription medication. Instead in recent years, milder synthetic and natural derivatives have become popular alternatives to Retinoic acid. These derivatives are metabolized to the active form by skin cells. Retinol (Vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits.




Hydroxypinacolone Retinoate is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful-looking skin with better consumer acceptance. The mechanism of action of Hydroxypinacolone Retinoate is advanced compared to retinol derivatives. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. Hydroxypinacolone Retinoate is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. Hydroxypinacolone Retinoate is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid.

 Scientific clinical data for HP Retinoate in Synergist Eye Night Treatment on improvements of aging skin


These results add credence to the beneficial safety and irritation profile of Hydroxypinacolone Retinoate as a topical cosmetic. The low irritation profile of Hydroxypinacolone Retinoate versus retinol was demonstrated on a 24-hour occlusive patch test and can be seen in Image 2.


Scientific clinical data for Synergist Eye Night's HP retinoate patch test for sensitivity




22 female volunteers applied to the contour of one eye a gel containing unique peptide complexes for 56 days against placebo on the other one. The anti-dark circle effect is assessed by image analysis and measurement of the color parameters (L,a,b system) by a specific software.

Scientific clinical data for Synergist Eye Night's Peptide Complexes' effectiveness on improvements for dark under eye circles





23 female volunteers aged from 42 to 67 years / Twice daily application on one half of the face of a cream containing Peptide Complexes against placebo, for 2 months. Assessment of the anti-wrinkle efficacy by profilometry, cutometry and photography compared to T0.


Scientific clinical data before and after photos for the effectiveness of Synergist Eye Night Peptide Complexes on wrinkles, skin tone, elasticity and firmness