BIO-10 COMPLEX is an innovative complex of Biomimetic Peptide & Red Clover Extract that targets the main causes of hair loss.
HAIR GROWTH CYCLE
Hair loss, also called alopecia, is a common problem affecting both men and women which also affects self-esteem and self-confidence.
Normal hair follicle is surrounded by healthy connective tissue and dermal papilla, and has minimal or absence of inflammation nor oxidative stress. Hair loss sufferers will most of the time have the hair growth cycle disrupted by an increase of dihydrotestosterone (DHT) hormone, loss of connective tissue integrity surrounding the hair follicle, and an increase of the inflammatory process and oxidative stress in the scalp. With age, the decrease number and size of hair follicles in the scalp will also lead to thinner hair and an increase in hair loss.
SYNERGISTIC ACTION OF OUR BIO-10 COMPLEX
BIO-10 is a biomimetic peptide (acetyl tetrapeptide-3) combined with a red clover extract rich in Biochanin A. BIO-10 efficacy is based on the association and synergistic action of its two ingredients.
BIO-10 has a direct action on 5- α -reductase which modulates dihydrotestosterone (DHT) to help prevent hair miniaturization. It improves ECM proteins integrity in dermal papilla for a better hair anchoring and reduces damages caused by inflammation, providing fuller, thicker and healthier looking hair.
TARGETING CAUSES OF HAIR LOSS
IL-1 α mimics the inflamation process in human fibroblasts and induces IL-8, a 450 pro-inflamatory cytokine.
BIO-10 helps decrease pro-inflammatory cytokines
DHT modulation via 5-α-reductase activity
DHT is formed by the action of 5-α-reductase on testosterone. DHT causes hair loss by shortening the growth cycle, producing progressively shorter and finer hair. This is the study of the capacity of Biochanin A to inhibit the 5-α-reductase activity in comparison with a well-known 5-α-reductase inhibitor EGCG (epigallocatechin gallate a potent antioxidant found in tea).
Biochanin-A inhibits 5-α-reductase activity.
ECM renewal and anchoring improvement
Hair follicles size is determined by:
- The volume of its dermal papilla;
- The volume of the extracellular matrix.
Healthy dermal papilla will produce good ECM proteins such as collagen type III and anchoring fibers such as laminin and collagen VII which will favor a good hair anchoring in the bulb surrounding tissue. If improper ECM renewal, hair will eventually lack vigor and will thin. Cycle after cycle, the follicle becomes smaller and finally, miniaturized and fall.
Proline is an amino acid constituent of collagen, therefore it represents a good indication
of newly synthesized collagen.
Acetyl tetrapeptide-3 stimulates collagen productiion for better ECM integrity leading to a better anchoring.
Quantification of laminin, type III collagen synthesis induced by Acetyl tetrapeptide-3 on fibroblasts. It has been demonstrated that molecules which have an activity on these ECM proteins stimulation, also increase hair follicle size and improve hair anchoring.
Acetyl tetrapeptide-3 stimulates dermal papilla extracellular matrix proteins, and thus has a direct effect on structures surrounding hair follicles.
Collagen VII is a major constituent of the anchoring fibrils and is located in the basement membrane (DEJ) around the papilla. In this experiment, corticoids are used to induce a decrease in the hair papilla cells growth and ECM protein.
Acetyl tetrapeptide-3 provides a repairing effect at the dermal-epidermal junction level, helping hair anchoring.
IMPROVING HAIR FOLLICLE LENGTH
Human hair follicles in anagen phase are isolated from skin biopsys and cultured with or without Acetyl tetrapeptide-3 for 8 days.
Acetyl tetrapeptide-3 improves by 35% the length in comparison with untreated areas after 8 days of treatment.
PROVIDING VISIBLY FULLER AND THICKER HAIR
- 30 men with androgenetic alopecia: 15 treated with 5% BIO-10 and 15 with placebo.
- Daily application of 20 drops of BIO-10 or placebo for a period of 4 months
- A digital trichogram (TrichoScan professional) was taken at DO and 4 months later.
Bio-10 induces a visible increase in the anagen hair density in comparison with placebo.
Bio-10 induces a strong reduction in the telogen hair density in comparison with placebo.
Bio-10 increases the A/T ratio by 46%