SYNERGIST

The New Gold-Standard In Skincare for Aging & Damaged Skin...and the science proves it.

 

SYNERGIST CEF COMPLEX: Collagen & Elastin Filler

SYNERGIST Micro-Targeted Deep Crease Serum™ Collagen Synthesis Reactivator 

is clinically proven to deliver equivalent results to one injection of collagen filler in just two weeks of regular use.

Upon aging, cells are no longer able to produce collagens and elastin effectively. By providing a new source of bio-energy this production is reactivated.
Synergist CEF Complex boosts senescent fibroblasts to:

  • 190% Increase in elastin production after 11 days
  • 179% Increase in collagen I production , and 194% Increase in collagen III production after 11 days
  • 50% decrease in skin laxity after 28 days
  • Improved skin clarity for rosacea patients due to a reduction in capillary branching, length and clarity within 12 weeks
  • Firmness increased by 13 times in 15 days
  • Reduces wrinkles’ depth by 15%, and volume by 13% in only 15 days 80% inhibition of MMP enzyme activity (types 1 and 2)
  • 85% increase in hyaluronic acid synthesis in vitro tests
  • Improvements sustained after two months of treatment

 

Scientific clinical data and photos of Synergist Micro-targed Deep Crease Serum on wrinkles before and after improvements

Biological Activity

Production of total collagen, collagens I and III ( ex vivo tests)

The action of Synergist CEF Complex on total collagen production was evaluated on skin explants from a 74 years old donor. Skin explants were either untreated or treated with 0.5% of CEF Complex at day 0, day 1, day 4, day 6 and day 8. Explants were then sampled analyzed at day 0, day 6 and day 11. Total collagen was detected with staining assessed by microscopical observation and image analysis.

    Synergist Micro-Targeted Deep Crease Serum™ effects and positive improvements on total collagen production

    Results: Synergist CEF Complex used at 0.5% increases the quantity of total collagen by 6.8% in 11 days.

     

    Scientific clinical data on Synergist Micro-Targeted Deep Crease Serum™ improvements on fibroblasts vitality

    Results: Synergist CEF Complex dramatically increases the vitality of young and aged fibroblasts. Aged fibroblasts are enabled to function properly again.

     

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ on improvement in Pro-collagen production

    Results: CEF Complex increases the synthesis of Pro-collagen I in a dose dependent way. Aged fibroblasts show even better ratio of production compared to young fibroblasts.

    *p<0.01 compared to untreated.Student t-test

    **p<0.001 compared to untreated. Student t-test

     

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ on inhibition of MMP enzymatic activity

    Synergist CEF Complex inhibits more than 80% of MMP enzymes activity (Types 2 and 9). The MMP-12 enzyme is also inhibited by Synergist CEF Complex.

     

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ reduction in rosacea

    23 volunteers (27 enrolled) with mild to moderate rosacea, visible telangiectases.

    Randomized split-face, double-blind trial, 12 weeks with a 5% Synergist CEF Complex cream or placebo.

     

    BIOLOGICAL ACTIVITY

    After studying the total collagen, two different types of collagens were quantitatively evaluated by immuno-staining: collagen I (in green fluorescent), and collagen III (in dark rose), also known as the youth collagen.

     

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ on biological activity and several types of collagen improvement

    Results: Synergist CEF Complex at 0.5% significantly increases collagen I and collagen III synthesis by +179% and +194% respectively after 11 days, versus untreated. Upon aging, the ratio of collagen I / collagen III is increased. With Neodermyl® at 0.5%, this ratio is decreased to the level of a younger skin: it moves from 0.82 to 0.55.

     

    Production of elastin (ex vivo tests)

    The action of Synergist CEF Complex on tropoelastin and elastin production was evaluated by following the same protocol as for collagen I and III. Tropoelastin (in green fluorescent) and elastin (in green fluorescent) were detected by immunostaining assessed by microscopical observation and image analysis.

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ on production of elastin

    Results: Synergist CEF Complex significantly increases tropoelastin and elastin production by +57% and +190% respectively after 11 days, versus untreated.

     

    Efficacy

    Fast improvement of firmness and elasticity 

    The two parameters R0 and R5 were measured by Cutometry to evaluate the performance of Synergist CEF Complex at 1% on firmness and elasticity.

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum on improvement of firmness and elastin

    Results: Using Synergist CEF Complex at 1% increases firmness by 13 times and elasticity by 1.6 times in only 15 days. These improvements of skin parameters are sustained after two months of treatment.

     

    Wrinkles' profiles confirm the benefits of using Synergist CEF Complex at 1% . After 15 days, the results are outstanding:

    Scientific clinical data for Synergist Micro-Targeted Deep Crease Serum™ on dramatic wrinkle improvement

    Results: The skin is smooth and wrinkles are visibly reduced after only 15 days of treatment with Synergist CEF Complex use at 1%.

     

    Synergist CEF Complex delivers equivalent results to one injection of collagen filler in just 2 weeks - 15% of wrinkles reduction

    Source: American Society of Plastic Surgeons

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