CLINICALS - SYNERGIST Micro-Targeted Deep Crease Serum™ Collagen Synthesis Reactivator
The New Gold-Standard In Skincare for Aging & Damaged Skin...and the science proves it.
SYNERGIST CEF COMPLEX: Collagen & Elastin Filler
SYNERGIST Micro-Targeted Deep Crease Serum™ Collagen Synthesis Reactivator
is clinically proven to deliver equivalent results to one injection of collagen filler in just two weeks of regular use.
Upon aging, cells are no longer able to produce collagens and elastin effectively. By providing a new source of bio-energy this production is reactivated.
Synergist CEF Complex boosts senescent fibroblasts to:
- 190% Increase in elastin production after 11 days
- 179% Increase in collagen I production , and 194% Increase in collagen III production after 11 days
- 50% decrease in skin laxity after 28 days
- Improved skin clarity for rosacea patients due to a reduction in capillary branching, length and clarity within 12 weeks
- Firmness increased by 13 times in 15 days
- Reduces wrinkles’ depth by 15%, and volume by 13% in only 15 days 80% inhibition of MMP enzyme activity (types 1 and 2)
- 85% increase in hyaluronic acid synthesis in vitro tests
- Improvements sustained after two months of treatment
Production of total collagen, collagens I and III ( ex vivo tests)
The action of Synergist CEF Complex on total collagen production was evaluated on skin explants from a 74 years old donor. Skin explants were either untreated or treated with 0.5% of CEF Complex at day 0, day 1, day 4, day 6 and day 8. Explants were then sampled analyzed at day 0, day 6 and day 11. Total collagen was detected with staining assessed by microscopical observation and image analysis.
Results: Synergist CEF Complex used at 0.5% increases the quantity of total collagen by 6.8% in 11 days.
Results: Synergist CEF Complex dramatically increases the vitality of young and aged fibroblasts. Aged fibroblasts are enabled to function properly again.
Results: CEF Complex increases the synthesis of Pro-collagen I in a dose dependent way. Aged fibroblasts show even better ratio of production compared to young fibroblasts.
*p<0.01 compared to untreated.Student t-test
**p<0.001 compared to untreated. Student t-test
Synergist CEF Complex inhibits more than 80% of MMP enzymes activity (Types 2 and 9). The MMP-12 enzyme is also inhibited by Synergist CEF Complex.
23 volunteers (27 enrolled) with mild to moderate rosacea, visible telangiectases.
Randomized split-face, double-blind trial, 12 weeks with a 5% Synergist CEF Complex cream or placebo.
After studying the total collagen, two different types of collagens were quantitatively evaluated by immuno-staining: collagen I (in green fluorescent), and collagen III (in dark rose), also known as the youth collagen.
Results: Synergist CEF Complex at 0.5% significantly increases collagen I and collagen III synthesis by +179% and +194% respectively after 11 days, versus untreated. Upon aging, the ratio of collagen I / collagen III is increased. With Neodermyl® at 0.5%, this ratio is decreased to the level of a younger skin: it moves from 0.82 to 0.55.
Production of elastin (ex vivo tests)
The action of Synergist CEF Complex on tropoelastin and elastin production was evaluated by following the same protocol as for collagen I and III. Tropoelastin (in green fluorescent) and elastin (in green fluorescent) were detected by immunostaining assessed by microscopical observation and image analysis.
Results: Synergist CEF Complex significantly increases tropoelastin and elastin production by +57% and +190% respectively after 11 days, versus untreated.
Fast improvement of firmness and elasticity
The two parameters R0 and R5 were measured by Cutometry to evaluate the performance of Synergist CEF Complex at 1% on firmness and elasticity.
Results: Using Synergist CEF Complex at 1% increases firmness by 13 times and elasticity by 1.6 times in only 15 days. These improvements of skin parameters are sustained after two months of treatment.
Wrinkles' profiles confirm the benefits of using Synergist CEF Complex at 1% . After 15 days, the results are outstanding:
Results: The skin is smooth and wrinkles are visibly reduced after only 15 days of treatment with Synergist CEF Complex use at 1%.
Synergist CEF Complex delivers equivalent results to one injection of collagen filler in just 2 weeks - 15% of wrinkles reduction
Source: American Society of Plastic Surgeons